Publications
2025
Nanoscale curvature regulates YAP/TAZ nuclear localization through nuclear deformation and rupture
Emmet A Francis, Einollah Sarikhani, Vrund Patel, Dhivya Pushpa Meganathan, Leah Sadr, Anum Tahir, Zeinab Jahed, Padmini Rangamani, Advanced Science, 2025. Online↗
A Dynamic Spike Sorter for Multiscale Nanoelectrode Array Recordings
Shivani Shukla, Callum Walsh, Shashank Bansal, Johannes Leugering, Abhinav Uppal, Vikrant Jaltare, Gert Cauwenberghs, Sreekanth H Chalasani, Zeinab Jahed, Advanced Materials Interfaces, 2025. Online↗
Machine learning for automated identification of anatomical landmarks in ultrasound periodontal imaging
Baiyan Qi, Lekshmi Sasi, Suhel Khan, Jordan Luo, Casey Chen, Keivan Rahmani, Zeinab Jahed, Jesse V Jokerst, Dentomaxillofacial Radiology, 2025. Online↗
Bioelectronic tools for understanding the universal language of electrical signaling across species and kingdoms
Shivani Shukla, Colin J Comerci, Gürol M Süel, Zeinab Jahed, Biosensors and Bioelectronics, 2025. Online↗
Single Nanocrown Electrodes for High‐Quality Intracellular Recording of Cardiomyocytes
Ching‐Ting Tsai, Hongyan Gao, Csaba Forro, Yang Yang, Viktoriya Shautsova, Xingyuan Zhang, Zeinab Jahed, Bianxiao Cui, Advanced Materials Interfaces, 2025. Online↗
Intelligent in-cell electrophysiology: Reconstructing intracellular action potentials using a physics-informed deep learning model trained on nanoelectrode array recordings
The levels of the long noncoding RNA MALAT1 affect cell viability and modulate TDP-43 binding to mRNA in the nucleus
Adarsh Balaji, Aileen C Button, Simone D Hall, Jonathan Zhu, Lauren Ellis, Ellen Lavorando, Ethan L Ashley, Raul Johnson, Einollah Sarikhani, Zeinab Jahed, Colleen A McHugh, Journal of Biological Chemistry, 2025. Online↗
2024
Engineering the Cellular Microenvironment: Integrating Three-Dimensional Nontopographical and Two-Dimensional Biochemical Cues for Precise Control of Cellular Behavior
Einollah Sarikhani, Dhivya Pushpa Meganathan, Anne-Kathrine Kure Larsen, Keivan Rahmani, Ching-Ting Tsai, Chih-Hao Lu, Abel Marquez-Serrano, Leah Sadr, Xiao Li, Mingdong Dong, Francesca Santoro, Bianxiao Cui, Lasse Hyldgaard Klausen*, Zeinab Jahed*, ACS NANO, 2024. Online↗
Engineered Nanotopographies Induce Transient Openings in the Nuclear Membrane
Einollah Sarikhani, Vrund Patel, Zhi Li, Dhivya Pushpa Meganathan, Keivan Rahmani, Leah Sadr, Ryan Hosseini, Diether Visda, Shivani Shukla, Hamed Naghsh‐Nilchi, Adarsh Balaji, Gillian McMahon, Shaoming Chen, Johannes Schöneberg, Colleen A McHugh, Lingyan Shi, Zeinab Jahed, Advanced Functional Materials, 2024. Online↗
Plasma membrane curvature regulates the formation of contacts with the endoplasmic reticulum
Yang Yang, Luis A Valencia, Chih-Hao Lu, Melissa L Nakamoto, Ching-Ting Tsai, Chun Liu, Huaxiao Yang, Wei Zhang, Zeinab Jahed, Wan-Ru Lee, Francesca Santoro, Jen Liou, Joseph C Wu, Bianxiao Cui, Nature Cell Biology, 2025. Online↗
Supra-and sub-threshold intracellular-like recording of 2D and 3D neuronal networks using nanopillar electrode arrays
Shivani Shukla, Joshua L Schwartz, Callum Walsh, Wen Mai Wong, Vrund Patel, Yu-Peng Hsieh, Chichi Onwuasoanya, Shaoming Chen, Andreas Offenhäusser, Gert Cauwenberghs, Francesca Santoro, Alysson R Muotri, Gene W Yeo, Sreekanth H Chalasani, Zeinab Jahed, Microsystems & Nanoengineering, 2024. Online↗
Nanoscale in silico and in vitro modeling of lipid bilayers for curvature induction and sensing
Ghafar Yerima, Ching-Ting Tsai, Chih-Hao Lu, Bianxiao Cui, Zeinab Jahed, Mohammad RK Mofrad, Biological Physics and Mechanics, 2024. Online↗
Multimodal Imaging Unveils the Impact of Nanotopography on Cellular Metabolic Activities
Zhi Li, Einollah Sarikhani, Sirasit Prayotamornkul, Dhivya Pushpa Meganathan, Zeinab Jahed, Lingyan Shi, Chemical & Biomedical Imaging, 2024. Online↗
Plasma membrane curvature regulates the formation of contacts with the endoplasmic reticulum
Yang Yang, Luis A Valencia, Chih-Hao Lu, Melissa L Nakamoto, Ching-Ting Tsai, Chun Liu, Huaxiao Yang, Wei Zhang, Zeinab Jahed, Wan-Ru Lee, Francesca Santoro, Jen Liou, Joseph C Wu, Bianxiao Cui, Nature Cell Biology, 2024. Online↗
2023
Force transmission and SUN-KASH higher-order assembly in the LINC complex models
Ghafar Yerima, Nya Domkam, Jessica Ornowski, Zeinab Jahed*, Mohammad RK Mofrad*, Biophysical Journal, 2023. Online↗
Curved Adhesions mediate cell attachment to soft matrix fibers in three dimensions
Wei Zhang, Chih-Hao Lu, Melissa L Nakamoto, Ching-Ting Tsai, Anish R Roy, Christina E Lee, Yang Yang, Zeinab Jahed, Xiao Li, Bianxiao Cui, Nature Cell Biology, 2023. Online↗
A NanoCurvS platform for quantitative and multiplex analysis of curvature-sensing proteins
Chih-Hao Lu*, Ching-Ting Tsai*, Taylor Jones IV, Vincent Chima, Lasse H. Klausen, Wei Zhang, Xiao Li, Zeinab Jahed *, Bianxiao Cui*, Biomaterials Science, 2023. Online↗
Modulation of nuclear membrane repair machinery by nano-needle arrays
Ryan Hosseini, Shivani Shukla, Einollah Sarikhani, Dhivya Meganathan, Rutuja Badle, Leah Spain, Jonathan Okerblom, Ching-Ting Tsai, Bianxiao Cui, Zeinab Jahed, Biophysical Journal, 2023. Online↗
Engineering cell morphology using maskless 2D protein micropatterning on 3D nanostructures
Einollah Sarikhani, Lasse Klausen, Dhivya Pushpa Meganathan, Abel Marquez Serrano, Ching-Ting Tsai, Bianxiao Cui, Zeinab Jahed, Biophysical Journal, 2023. Online↗
Membrane curvature sensed and induced by formin binding Protein 17
Abdel-Ghafar Yerima, Zeinab Jahed, Mohammad Mofrad, Biophysical Journal, 2023. Online↗
A versatile nanoelectrode platform for electrical recording of diverse cell types
Shivani R Shukla, Ching-Ting Tsai, Zeinab Jahed, Bianxiao Cui, Biophysical Journal, 2023. Online↗
2022
Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes
Zeinab Jahed*, Y Yang*, CT Tsai*, EP. Foster, AF. McGuire, H Yang, A Liu, C Forro, Z Yan, XJ. Ke, M Zhao, W Zhang, X Li, T Li, A Pawlosky , J C. Wu, B Cui. Nature Communications, 2022. Online↗
Intracellular recording of cardiac action potentials via membrane electroporation
Bianxiao Cui, Zeinab Jahed, Yang Yang, Ching-Ting Tsai, Biophysical Journal, 2022. Online↗
2021
Molecular models of LINC complex assembly at the nuclear envelope
Zeinab Jahed, Nya Domkam, Jessica Ornowski, Ghafar Yerima, Mohammad RK Mofrad, Journal of Cell Science, 2021. Online↗
Exploring cell surface-nanopillar interactions with 3D super-resolution microscopy
AR. Roy, W Zhang, Zeinab Jahed, CT Tsai, B Cui, W.E. Moerner, ACS Nano, 2021. Online↗
Nanoscale surface topography reduces focal adhesion and cell stiffness by enhancing integrin endocytosis
X Li, L Klausen, W Zhang, Zeinab Jahed, CT Tsai, T Li; B Cui, Nanoletters, 2021. Online↗
2020
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Zeinab Jahed*, N Domkam, J Ornowsky, G Yerima, MRK Mofrad*, “Molecular models of LINC complex assembly at the nuclear envelope”. Journal of cell science (in-press 2021) *co-corresponding
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C Lubrano, GM Matrone, C Forro, Z Jahed, A Offenhaeusser, A Salleo, BCui, F Santoro. “Towards biomimetic electronics that emulate cells”. MRS Communications (2020)
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Z Haydari, H Shams, Z Jahed, MRK Mofrad. Kindlin assists talin to promote integrin activation, Biophysical Journal (2020)
2019
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Z Jahed, H Hao, V Thakkar,UT. Vu, VA. Valdez, A Rathish, C Tolentino, SC.J. Kim, D Fadavi, DA. Starr, MR.K. Mofrad “Role of KASH domain lengths in the regulation of LINC complexes”, Molecular Biology of the Cell. In Press. (2019) **Nominated for MBoC paper of the year award
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Z Jahed, MRK Mofrad “The Nucleus Feels the Force, LINCed in or Not!”, Current Opinion in Cell Biology (Themed issue on Cell nucleus). (2019)
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Z Jahed, Z Haydari, A Rathish, MRK Mofrad “Kindlin Is Mechanosensitive: Force-Induced Conformational Switch Mediates Cross-Talk among Integrins”, Biophysical Journal. (2019). ** Highlighted by Biophysical Society
2018
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Z Jahed, UT Vu, D Fadavi, H Ke, A Rathish, S Kim, W Feng, MRK Mofrad “A Molecular Model for LINC complex regulation: activation of SUN2 for KASH binding”, Molecular Biology of the Cell.(2018)
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NE Cain, Z Jahed, A Schoenhofen, VA Valdez, B Elkin, H Hao, NJ Harris, LA Herrera, BM Woolums, MRK Mofrad, GWG Luxton, and DA Starr, “Conserved SUN-KASH interfaces mediate LINC complex-dependent nuclear movement and positioning events”, Current Biology. (2018)
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Z Jahed, MRK Mofrad, “Mechanical LINCs of the nuclear envelope: Where SUN meets KASH”, Extreme Mechanics Letters (special issue on Mechanobiology). (2018)
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Z Jahed, D Fadavi, U Vu, E Asgari, G.W. G. Luxton, MRK Mofrad, “Molecular Insights into Mechanism of SUN1 oligomerization in the Nuclear Envelope”, Biophysical Journal. (2018)
<2017
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Z Jahed, H Shahsavan, MS Verma, JL Rogowski, BB Seo, B Zhao, TY Tsui, FX Gu, MRK Mofrad. “Bacterial Networks on Hydrophobic Micropillars”. ACS Nano. (2017) ** Journal cover
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Z Jahed, R Zareian, YY Chau, BB Seo, M West, TY Tsui, W Wen, MRK Mofrad. “Differential Collective and Single Cell Behaviors on Silicon Micropillar Arrays”. ACS Applied Materials & Interfaces. (2016)
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Z Jahed, M Soheilypour, M Peyro, MRK Mofrad. “The LINC and NPC relationship–it's complicated!”, Journal of Cell Science. (2016)
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M Soheilypour, M Peyro, Z Jahed. On the Nuclear Pore Complex and Its Roles in Nuclei-Cytoskeletal Coupling and Mechanobiology, Cellular and Molecular Bioengineering. (2016)
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Z Jahed, H Shams, MRK Mofrad. “A disulfide bond is required for the transmission of forces through SUN-KASH complexes.” Biophysical Journal. (2015)
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Z Jahed, P Lin, BB Seo, MS Verma, FX Gu, TY Tsui, MRK Mofrad. “Responses of Staphylococcus aureus bacterial cells to nanocrystalline nickel nanostructures”. Biomaterials. (2014) ** Media mentions
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Z Jahed, S Molladavoodi, BB Seo, M Gorbet, TY Tsui, MRK Mofrad. “Cell responses to metallic nanostructure arrays with complex geometries”. Biomaterials. (2014)
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Z Jahed, H Shams, M Mehrbod, MRK Mofrad. “Mechanotransduction pathways linking the extracellular matrix to the nucleus.” International review of cell and molecular biology. (2013)
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H Shams, BD Holt, SH Mahboobi, Z Jahed, MF Islam, KN Dahl, MRK Mofrad. “Actin Reorganization through Dynamic Interactions with Single-Wall Carbon Nanotubes.” ACS nano. (2013)
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Y Tsui, Z Jahed, S Jin, MJ Burek. “Suppression of size-dependent softening effects in sub-micron nanocrystalline ruthenium columnar structures”. Materials Science and Engineering: A. (2013)
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Z Jahed, K Shaban, HR Tizhoosh. “Multi-stage Intra-patient template matching for prostate detection in MR volumes”. IEEE Engineering in Medicine and Biology Society (EMBC). (2013)
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Z Jahed, S Jin, MJ Burek, TY Tsui. “Fabrication and buckling behavior of polycrystalline palladium, cobalt, and rhodium nanostructures”. Materials Science and Engineering: A. (2012)
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Z Jahed, RD Evans, MJ Burek, TY Tsui. “Mechanical properties of columnar submicron cobalt structures with various cross-sectional geometries”. Scripta Materialia. (2012)
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MJ Burek, AS Budiman, Z Jahed, et al., “Fabrication, microstructure, and mechanical properties of tin nanostructures”. Materials Science and Engineering: A. (2011)
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MJ Burek, S Jin, MC Leung, Z Jahed, J Wu, AS Budiman, N Tamura. “Grain boundary effects on the mechanical properties of bismuth nanostructures”. Acta Materialia. (2011)